A disease-centered research initiative
Integrating cellular, molecular and clinical landscapes to understand tumor biology and therapeutic opportunities.
Featured atlases
Each atlas brings multiple scales of evidence into a coherent view of disease biology.
A pan-sarcoma reference atlas of malignant and microenvironmental programs, with a focused investigation of uterine leiomyosarcoma.
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A multi-omic investigation of tumor states, dissemination patterns, microenvironmental ecosystems and therapeutic vulnerabilities in high-grade serous ovarian cancer.
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Our scientific approach
Cells
→States
→Programs
→Ecosystems
→Phenotypes
→Therapies
We connect cell states and multicellular ecosystems to clinical phenotypes—then ask which dependencies can become therapeutic opportunities.
Research foundation
Advanced Science
Plasma cfRNA sequencing and deep learning enable non-invasive ovarian cancer detection and prediction of platinum resistance.
Communications Biology
A single-cell transcriptional landscape spanning normal ovary, endometriosis, primary and recurrent ovarian clear cell carcinoma.
Journal for ImmunoTherapy of Cancer
Single-cell, TCR and spatial profiling resolves genetic and treatment-associated immune ecosystems in ovarian clear cell carcinoma.
Clinical and Translational Medicine
Matched primary and metastatic tumors reveal malignant heterogeneity, regulatory programs and epithelial–fibroblast communication.